NEUROSTEROID BASED DISORDERS
The neuropsychiatric and neurologic disorders listed to the right all show reduced and dysregulated neurosteroid levels.
Disorders 1-11 (Studies Using Etifoxine)
Etifoxine has demonstrated preclinical efficacy in each of these 11 disorders, by enhancing neurosteroid tone. All research data is provided in published studies, which are available under the Publications tab.
Etifoxine Reduces Neuropathic and Inflammatory Pain
A number of studies detail etifoxine’s efficacy in models of neuropathic and inflammatory pain. The compound was not only able to reduce the response to pain symptoms, but directly affect the reduction of inflammatory factors, like TNF-α and IL-6. For supporting studies click here.
All of these pre-clinical studies were conducted using dose levels of etifoxine consistent with anxiolytic activity.
Etifoxine has Neuroregenerative/Neuroprotective Properties
Etifoxine has demonstrated efficacy in several models of multiple sclerosis, brain injury and stroke, direct nerve injuries, acellular nerve grafts, retinal degeneration and epilepsy. Etifoxine has been shown to upregulate nerve growth factors, such as GDNF, BDNF and NGF. Notably, etifoxine has also been revealed as a very effective microglia modulator. Microglia modulators are the focus of intense investigation in neurodegenerative diseases, like Alzheimer’s. For supporting studies click here.
Disorder 12 – Depression
11% of Etifoxine prescriptions in France were off-label for depressive episodes (based on 2016 data accounted for).
Disorder 13 – Postpartum Depression
Phase 2 clinical studies have demonstrated that intra-venous infusion of neurosteroid ALLO rapidly and significantly relieves symptoms in women suffering from severe postpartum depression. View study.